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50 Gems of South Yorkshire: The History & Heritage of the Most Iconic Places

為了解決History of landscape的問題，作者Handley, Christine,Rotherham, Ian D. 這樣論述：

The county of South Yorkshire covers Barnsley, Doncaster, Rotherham and Sheffield districts. Although each are major urban centres with their own range of civic buildings, museums and galleries, the county also ranges from low-lying farmlands in the east to high moorlands on the edge of the Peak

District National Park. It has a rich and diverse landscape including ancient woodlands, rivers and wetlands alongside the legacy of its history as an industrial powerhouse built on coal, steel and heavy engineering, including Kelham Island in Sheffield, Wortley Top Forge and Silkstone Tramway in Ba

rnsley, and Clifton Museum in Rotherham. Away from the urban centres there are picturesque market towns and villages, such as Penistone, Tickhill, Bawtry, Bradfield, Thorpe Salvin and Tankersley which still serve rural farming communities, and stunning stately homes and parkland, for example at Went

worth Woodhouse, Canon Hall and Brodsworth Hall. Earlier medieval remains survive at Roche Abbey and Monk Bretton Priory, the castle keep at Conisbrough, the Lady Chapel on the bridge in central Rotherham and Ecclesfield Church, ’the Minster of the Moors’. There are also examples of the earliest hum

an settlement and activity at Wharncliffe Crags and Wincobank Hill in Sheffield. Other places have associations with historical figures such as the sculptor Francis Chantrey and William Bradford, one of the Pilgrim Fathers. In 50 Gems of South Yorkshire authors Christine Handley and Ian Rotherham ex

plore the many places and their history that make this part of northern England so special, including many lesser known gems.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決History of landscape的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Not Even the Dead

為了解決History of landscape的問題，作者 這樣論述：

A claim of justice for the losers of history with echoes of authors as different as Joseph Conrad, Alejo Carpentier, and David Mitchell.The conquest of Mexico is over, and Juan de Toñanes is one of so many soldiers without glory who roam like beggars for the land they helped subdue. When he receives

one last mission, to hunt down a renegade Indian who’s called the Father and who preaches a dangerous heresy, he understands that this may be his last chance to carve himself the future he’s always dreamed of. But as he goes deep into the unexplored lands of the north following the Father’s trace,

he will discover the footprints of a man who seems not only a man, but a prophet destined to transform his time and even the times to come.Not Even the Dead is the story of a persecution that transcends territories and centuries; a path pointing northward, always northward, that is to say, always to

ward the future, on a hallucinated journey from the sixteenth century New Spain to today’s Trump wall. Old conquerors on horseback and migrants riding the roofs of the Beast, rebellious Indians and peasants waiting patiently for a better world, Mexican revolutionaries who take their rifles and women

murdered in the desert of Ciudad Juárez, all pass by it. All of them share the same landscape and the same hope, the arrival of the Father who will bring justice to the oppressed. Juan Goméz Barcenà (1984) holds degrees in literary theory, comparative literature, and history from the Complutense

University of Madrid, and a degree in philosophy from Spain’s National University of Distance Education. He’s the author of numerous essay, short story, and poetry collections, for which he’s received the José Hierro Prize for Poetry and Fiction, the International CRAPE Prize for stories, and the R

amón J. Sender Prize for Narrative, among others. He lives in Madrid.Katie Whittemore translates from the Spanish. Her work has appeared in Two Lines, The Arkansas International, The Common Online, Gulf Coast Magazine Online, The Brooklyn Rail, and InTranslation. Current projects include novels by

Spanish authors Sara Mesa, Javier Serena, Aliocha Coll, and Aroa Moreno Durán. She lives in Valencia.

透過基於基因本體之整合性分析識別卵巢上皮性腫瘤發病機轉的失調基因功能體

為了解決History of landscape的問題，作者蘇國銘 這樣論述：

上皮性卵巢癌（EOCs）在晚期或復發的婦科惡性腫瘤中常是致命的和頑固的，其中漿液性佔絕大多數而卵巢清亮細胞癌（OCCC）是僅次於漿液性上皮性卵巢癌的第二常見的上皮性卵巢癌。即便經過腫瘤減積手術後加上化學藥物治療後仍有不少的患者有著較差的預後或是復發，故整體而言，對於卵巢癌的治療仍是一個相當大的挑戰。此外，邊緣性卵巢腫瘤(BOT)，包括漿液性 BOT與黏液性BOT，是屬於介於良性與惡性之間的卵巢疾病，雖然大部分的預後不差但是也有與卵巢癌不同的組織病理學特性。本研究使用以基因本體(GO)為基礎加上機器學習輔助運算的綜合分析去探討卵巢清亮細胞癌以及漿液性卵巢腫瘤包含漿液性邊緣性卵巢腫瘤與漿液性卵巢

癌的GEO資料庫中失調的基因體、功能途徑，藉以去識別重要的差異表達基因(DEG)。首先在卵巢清亮細胞癌的整合性分析中，發現無論是早期抑或是晚期，與免疫功能相關尤其是活化補體系統的替代途徑的功能失調在腫瘤發生佔有相當重要的關聯性，而補體C3與補體C5也影響了疾病無惡化存活期(Progression-free survival, PFS)和整體存活率(Overall survival, OS)且免疫染色結果是有意義的。而在漿液性卵巢腫瘤的分析中發現，SRC基因和功能失調的芳烴受體(AHR)結合路徑(Binding pathway)確實影響PFS和OS，而且與上皮細胞間質轉化(Epithelial-

mesenchymal transition, EMT)相關的鋅指蛋白SNAI2在腫瘤發生過程中有重要角色，並顯示出從漿液性 BOT 到卵巢癌有著逐漸上升的影響趨勢。未來，標靶治療可以專注於這些有意義的生物標誌並結合精確監測，以提高治療效果和患者存活率。