Most importantly syn的問題，透過圖書和論文來找解法和答案更準確安心。 我們查出實價登入價格、格局平面圖和買賣資訊

痘苗病毒與宿主免疫之間的相互作用： 1.Vaccinia virus penetration factor (VPEF)/Fam21在 突細胞對抗白色念珠菌功能的重要性 2. 基於痘苗病毒的疫苗賦予保護性免疫敘利亞倉鼠中的 SARS-CoV-2 病毒。

為了解決Most importantly syn的問題，作者芮卡許 這樣論述：

1. 牛痘苗病毒(Vacv)屬於痘病毒科，是一種大型DNA病毒，宿主範圍廣，可感染哺乳動物細胞。我們之前對 HeLa 細胞的研究表明，牛痘成熟病毒被內吞到宿主細胞之胞內體中。在運送過程中利用胞內體內之pH酸化，病毒膜與胞內體膜融合，以釋放病毒內核進入細胞質，完成感染步驟。FAM21是 Wiskott-Aldrich Syndrome Protein and SCAR Homology (WASH) 蛋白複合物的一個組成成分，可介導內體膜上的肌動蛋白聚合，以促進含有貨物的囊泡從內體中分離出來。為了研究 FAM21 的體內功能，我們在 C57BL/6 小黑鼠中產生 FAM21 之剔除小鼠，主要以

表現FAM21 之CD11c 樹突細胞群作為剔除對象。來自 FAM21 (KO) 小鼠的骨髓衍生樹突細胞 (BMDC) 其吞噬能力、抗原修飾作用以及T細胞活化功能降低，可見得 FAM21 在樹突細胞 (DC) 功能中具有關鍵作用。 FAM21 KO BMDC細胞形態及細胞極性(Polarity)均有改善，因而影響到細胞移動。利用RNA微矩列分析 WT 和 FAM21 KO BMDC確定了TLR2/Clec4e訊息傳導路徑在 FAM21 KO 中減少。最後我們利用白色念珠菌感染小鼠膜腹腔中表現 KO老鼠 (1)抵抗力下降，死亡率增加 (2) 體內TLR2/Clec4e活化程度下降 (3) 白色念

珠菌在腎臟生長量增高。總結以上實驗結果證明FAM21對樹突細胞調節TLR2/Clec4e路徑十分重要。2. 新冠病毒 (SARS-CoV-2) 屬於冠狀病毒的 β 家族且可引起COVID-19的疾病。 SARS-CoV-2 導致 10-15% 的感染者顯現嚴重呼吸系統病徵以及 2-3% 的 死亡率，因此迫切需要疫苗來預防感染和控制病毒傳播。儘管目前市場上已 有以 mRNA 及腺病毒為基礎而產生的疫苗，但是它們對“冷鏈”運輸的依賴性 使得全球疫苗接種成為一項艱鉅的任務。在此情況下，穩定而易於輸送的凍 乾疫苗應有某些優勢。因此，建立另外的疫苗平台對因應 SARS CoV-2 和 未來出現的突變株仍

然至關重要。 牛痘苗病毒 (VACV) 已被用於根除天花疾病，而且具有便宜及方便運送之優 點。近來更已開發出幾種針對人類具有更高安全性的減毒病毒株。我們建構 了兩種痘苗病毒株 MVA-S 和 v-NY-S來表達全長 SARS-CoV-2 棘狀蛋白質 。 MVA-S 在哺乳動物細胞中生長受限且較為安全，而 v-NY-S 具有複製能 力刺激先天免疫效果較佳。此兩種疫苗在C57BL/6 小鼠中均可誘導出大量的 中和抗體，並產生了偏向 TH1 抗病毒的免疫反應。最重要的是，用 MVA-S 和 v-NY-S 對黃金倉鼠中進行感染，已接種疫苗之實驗組倉鼠可被保護，免 於 SARS-CoV-2 感染。可見得

這兩種疫苗是未來發展 最佳選擇。最後， 疫苗接種產生之中和抗體，並具有交叉中和 SARS-CoV-2 Delta 變異株之能力。

Effects of Physical Activity on Balance, Cognitive Function, and Depression in Stroke Survivors

為了解決Most importantly syn的問題，作者RENNY WULAN APRILIYASARI 這樣論述：

BackgroundStroke is the leading cause of disability. Stroke survivors with physical impairments (e.g., balance performance) and neuropsychiatric impairments (e.g., cognitive dysfunction and depression symptoms) experience a meaningful impact on their functional independence, recovery, and quality o

f life. Physical impairments are the most prioritized area of research related to life after stroke. Important outcomes related to physical impairments include balance and walking problems. Previous systematic reviews have supported the a beneficial of proprioceptive exercise in improving motor fun

ction, balance, and functional ability among healthy and various disease populations. However, its effectiveness for people with stroke has never been assessed using a systematic review and meta-analysis. Therefore, there is a need to assess up-to-date evidence to determine the effectiveness of prop

rioceptive training on balance, gait, trunk control, and basic functional mobility in stroke survivors.Another top priority related to life after stroke is cognitive function. Although the effectiveness of interventions that involve physical activity components for improving cognitive function in th

e elderly has been widely studied, there has been no systematic review summarizing the effects of interventions that have physical activity components on cognitive function in the stroke population.Moreover, adequate physical activities are crucial for the psychological health of an individual with

stroke. Physical activity could be a potential predictor of depressive symptoms. However, there have been conflicting results regarding the association between physical activity and poststroke depression. Most importantly, the association between physical activity and depression in the adult populat

ion with stroke in Indonesia has yet to be determined in a population-based study using nationwide data. To this end, determining whether meeting guidelines-recommended levels of physical activity is associated with a lower likelihood of depression among the Indonesian stroke population using a nati

onally representative sample is of clinical importance.ObjectiveThe specific aims of this dissertation were to: (1) investigate the effect of proprioceptive training on balance, gait, trunk control, and basic functional mobility in stroke survivors by conducting a meta-analysis of RCTs (study 1); (2

) evaluate the effectiveness of physical activity-related interventions for improving cognitive function in stroke survivors by conducting a systematic review of RCTs (study 2); (3) conduct a secondary analysis of data from the 2018 Basic Health Research (Riset Kesehatan Dasar, RISKESDAS) to examine

the association between physical activity and depression in Indonesian adults who reported having had a stroke (study 3).MethodsIn study 1, a systematic review and meta-analysis of randomized controlled trials was conducted. Searches of published articles in five electronic databases, including Pub

Med, Science Direct, Cochrane, Embase, and Medline, were performed from inception to July 26, 2021. Two reviewers independently screened the titles and abstracts of potentially eligible articles that were identified based on the search criteria. Methodological quality was determined using version 2

of the Cochrane risk of bias tool for randomized trials. Data were analyzed using Comprehensive Meta-Analysis software. The treatment effect was estimated by calculating Hedges' g and 95% confidence interval (CI) using a random-effects model. Statistical heterogeneity was assessed according to the

I2 value. The primary outcome was balance performance, and secondary outcomes were trunk control, gait speed, and basic functional mobility.In study 2, a systematic review of up-to-date evidence was conducted. We searched six electronic databases, namely PubMed, Cochrane, Embase, Medline Ovid, Scop

us, and CINAHL, from inception to June 10, 2021. Studies that used a randomized controlled trial design and assessed the effects of an intervention that involved any type of physical activity were included.In study 3, a cross-sectional study involving 3,234 adults with stroke based on the 2018 RISKE

SDAS data was conducted. Physical activity levels in metabolic equivalents (MET)-minutes per week averages were determined using the Global Physical Activity Questionnaire according to the World Health Organization (WHO) guidelines on physical activity and sedentary behavior recommendations. Depress

ion was assessed using the Mini-International Neuropsychiatric Interview (MINI). Multivariate binomial logistic regression analysis was performed to calculate the odds ratio (OR) of depression in those who met the WHO recommendation of physical activity compared with those did not after adjustment f

or confounders.ResultsStudy 1We included 17 studies with 447 stroke patients. Proprioceptive training had a significant impact on balance (Hedges’ g = 0.69, 95% CI=0.36 to 1.01), gait speed (Hedges’ g = 0.57, 95% CI = 0.19 to 0.94), trunk control (Hedges’ g = 0.75, 95% CI = 0.33 to 1.17), and basic

functional mobility (Hedges’ g = 0.63, 95% CI = 0.31 to 0.94) among stroke survivors.Study 2A total of 23 trials involving 1695 stroke survivors were included. Results from this review showed that physical activity-related interventions combined with cognitive training, acupuncture, or repetitive tr

anscranial magnetic stimulation tend to have better results in improving cognitive function in stroke survivors compared with physical activity-related intervention alone.Study 3Adults with stroke who met the WHO recommendation of physical activity were significantly associated with lower odds of de

pression after adjustment for confounders (OR = 0.757, p = 0.017).ConclusionIn stroke survivors, proprioceptive training was found to effectively improve motor functions, including balance performance, gait speed, trunk control, and basic functional mobility. Moreover, physical activity-related inte

rventions in combination with cognitive training and or acupuncture or repetitive transcranial magnetic stimulation revealed beneficial effects for improving cognitive function. Lastly, performing physical activity according to the WHO recommendation is associated with a reduced likelihood of depres

sion among Indonesian adults with stroke.