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偷書鬼

為了解決基隆市 圖書館 借 書證的問題，作者凱特 這樣論述：

史上最愛偷書、又愛寫書（但沒人願意出版）的女鬼！鬼齡97歲，鬼址古墓路四十三號！ 　　（本書採中英對照，附大量〈見鬼〉插圖） 　　顧先生個性古怪易怒，鐵齒不信鬼。 　　他是位暢銷作家，曾寫下家喻戶曉的《馴鬼人》系列，但那是二十年前的事了。 　　（如果這個夏天，他再寫不出第十三集《馴鬼人》，就要破產啦！） 　　為了專心寫作，他租下這棟擁有三十二間半臥室的豪宅，沒想到卻意外多了很多位室友：一個愛唱反調的十一歲男孩、一隻貓，還有原屋主──一隻死了九十七年的女鬼！ 　　這隻鬼生前寫了一本又一本的懸疑小說，但是從紐約到香港，都找不到一家出版社願意幫她出書（誰叫她不來台灣找「野人出版社」呢？），最後終於含

恨而死...... 　　當一個再也寫不出暢銷書的（過氣）作家，遇上做鬼都出不了書（只能偷書）的女作家，還要面對一個自稱看得見鬼的（鬼見愁）小男孩，他還能寫出叫好又叫座的（鬼扯）故事嗎？最後到底是人馴鬼，還是鬼馴人呢？ 注： 　　1.本故事鬼扯有趣，有益身心健康，還能同時增進「想像力」和「英語能力」！ 　　2.本書插圖中保證有鬼！一般人看不見是正常（看得見是「見鬼」），但絕非印刷錯誤，也不是鬼畫符！ 　　3.本書續集《Over my dead body》中文版預計2009年年底上市。 作者簡介 克莉絲姊妹攜手合作，凱特 / 文＋姊姊莎拉 / 圖 　　她們的父親是教育電影的製作人，家裡共有六個小孩

，在伊利諾州的皮瑞亞（Peoria）長大，小時候常和兄弟姊妹聆聽媽媽的床邊故事，排行老四的凱特在十歲那年首度和大她一歲的姊姊莎拉合作繪本。目前凱特於密蘇里州諾伍德市的農莊定居，創作之餘，也為〈人物〉雜誌撰稿。 譯者簡介 吳宜潔 　　臺大外文系畢業，英國瑞汀大學兒童文學碩士。曾任美國紐伯瑞金獎作家Linda Sue Park訪臺隨行口譯、臺北國際書展兒童館策展助理、基隆市文化局英語繪本講師。喜歡閱讀周圍的人，覺得平凡的事物裡裹著最深的奇幻。現為自由譯者，譯有《偽倫敦》、《生存遊戲》、《失控的邏輯課》、《閱讀兒童文學的樂趣》（合譯）、《星期三戰爭》、《愚人節說再見》等。 【鬼城日報】六月一日星期

天� � � � � � � � � � � � � � � � � � � � � � � � � � 1.5美元編輯：克理夫．漢爾� � � � � � 報導您的祕密就是我們的職責 � � � � � � � 早報------------------------------------------------------------------------------------------------------------------------名作家將於今夏入住鬼城　　今年六十四歲的暢銷〈馴鬼人〉系列作家伊格艾生契．B．顧仁願今夏將於鬼城度過。　　顧仁願租下古墓路四十三號的房子

，當地人都稱為「史艾書宅邸」。（故事詳見下文。）　　這棟房子現在為雷斯和戴安．希旺教授所有，正計畫出售。　　「在買家出現以前，希旺夫婦提供出租。」宜人房屋的安寧塔．麥女士表示。　　顧仁願拒絕接受任何採訪，只是不悅地說：「走開！」　　「他正著手進行〈馴鬼人〉新作，不希望接受任何干擾。」安寧塔從加州辦公室接受電話訪問時表示。　　「我個人認為，」安寧塔女士繼續說：「他是個老頑固，不過別把這句話登出來。」　（抱歉，安寧塔女士，報導妳的祕密是我們的職責！）　　　　　　　　　　當年對史艾書宅邸寄予的作家大夢，終告破滅　　伊格艾生契．B．顧仁願租下史艾書宅邸似乎再恰當不過。畢竟，已故的橄欖．C．史艾書一八七

四年興建這棟維多利亞大宅時，就是為了打造一座寫作殿堂。　　住在這棟宅邸期間，史艾書完成無數本懸疑小說，並親筆配上插圖。她更曾辦過無數場奢華派對，邀全鎮為完稿大肆慶功。　　然而，史艾書卻遍尋不著願意買下手稿的出版商，使她大為挫折。她那圖文並茂的作品，在當時顯然太過前衛。　　認識史艾書的人說，在一次次被拒絕後，她逐漸疏離人群。過世前幾年，終生未婚、膝下無子的史艾書幾乎足不出戶。九十七年前她離開人世，死因正是文學大夢幻滅而心碎。　　傳奇的是，就在史艾書過世前不久，她曾立誓要讓鬼城永不得寧靜，除非有人出版她的懸疑小說。　　「真是鬼話連篇。」「鬼城古董店」負責人麥可．歐布拉表示。多年來，聽說史艾書的身影

經常在店裡的一面古鏡中浮現，卻從未有人成功拍下照片為證。　　「那些閒人想要裝神弄鬼，那是他們的事。」歐布拉繼續說：「我可不信。」　　「鬼城寵物店」老闆貝瑞．埃．利福也不信，雖然只要有人提起史艾書的名字，店裡那隻高齡一九七的老烏龜波先生，嘴角總是揚起狡猾的微笑。　　不過，「鬼城烘焙坊」的店長雪莉．優．潔絲特，倒是再也不烤蜜桃派了。　　「我聽說那是橄欖最愛的甜點。」潔絲特說：「倒不是說我相信有鬼，只是每次我只要一烤蜜桃派，派就會從冷卻盤上不翼而飛。巧克力脆片瑪芬也是一樣。」　　十二年前，在宅邸閒置八十多年後，雷斯和戴安．希旺毅然買下這棟房子時，對它的來龍去脈可是一清二楚。夫妻兩人都是超自然現象界的

教授，目標在研究橄欖．C．史艾書的鬼魂，並能清楚偵測到它。　　「要是能讓橄欖的鬼魂現身，我們鐵定會大賺一筆。」偕同妻子搬進宅邸時雷斯．希旺表示。　　「我們將成為全美超自然現象界最有錢的教授，」戴安．希旺又說：「說不定是全世界！」　　然而，在一次次偵測鬼魂的實驗失敗以後，雷斯和戴安．希旺決定將房子出售。今年夏天他們將在歐洲巡迴，在一場名為「只有傻子（和孩子）相信鬼」的演講中，發表他們的實驗結論。　　不過，基於專業考量，他們將獨子西摩留在家中。圖書館藏書（又告）失蹤　　「鬼城公立圖書館」有一打童書不翼而飛。　　「我真是不懂，」總圖書館員巴姆先生說：「只要有圖書證就能免費借書，根本不必用偷的。麻煩偷

書的人趕緊歸還。」　　這十二本書，恰巧就是伊格艾生契．B．顧仁願寫的〈馴鬼人〉系列。　　這已經不是「鬼城公立圖書館」第一次發生竊書案或幽靈事件。　　「行行好，別這麼說可以嗎？」巴姆央求。THE GHASTLY TIMESSunday, June 1 ＄1.50 “Your Secrets Are Our Business Cliff Hanger, Editor Morning Edition Famous Author to Live in

Ghastly This SummerGrumply is renting local mansion.Ignatius B. Grumply, 64, author of the popular Ghost Tamer series of children’s books, will spend the summer right here in Ghastly. Grumply is renting the house at 43 Old Cemetery Rd., known locally as Spence Mansion. (See story below.) The house,

owned by Professors Les and Diane Hope, is for sale. “The Hopes are offering their house for rent until a buyer can be found,” said Anita Sale of Proper Properties.Grumply declined requests for interviews with a gruff “Go away!” “He’s working on a new book in the Ghost Tamer series, and he doesn’t w

ant to be bothered,” explained Sale in a phone interview from her office in California.“Personally,” continued Sale, “I think Ignatius Grumply is an old grouchypants, but don’t print that in the newspaper.” (Sorry, Anita. Your secrets are our business!)Spence Mansion Built on the Hope of a WriterWho

Died a FailureIt seems only fitting that Ignatius B. Grumply should rent Spence Mansion. After all, the Victorian house was built in 1874 by the late Olive C. Spence as a place to write. Spence wrote and illustrated dozens of mysteries while living in her three-story house. She threw elaborate part

ies for the whole town to celebrate the completion of her manuscripts. But much to her frustration, Spence could never find a publisher willing to buy her graphic mysteries, which were undoubtedly ahead of their time. Those who knew Spence say the continual rejection caused her to withdraw from soci

ety. In her final years, Spence, who never married or had children, rarely left the mansion. Her death 97 years ago was attributed to a heart broken by her failed literary career.Legend has it that shortly before her death, Spence vowed to haunt her house and the town of Ghastly for eternity or unti

l one of her mysteries was published, whichever came first. “That’s a lot of hogwash,” said Mac Awbrah, owner of Ghastly Antiques. Over the years Spence’s image has reportedly appeared in an old mirror in the antique shop. Attempts to photograph the image have failed.“If people want to believe in gh

osts, let’em,” continued Awbrah. “I certainly don’t.”Nor does Barry A. Lyve, owner of Ghastly Pet Store, where a 197-year-old giant tortoise named Mr. Poe curls its mouth into a sly smile whenever anyone mentions Spence’s name. But at the Ghastly Gourmand, owner Shirley U. Jest has given up baking p

each pies. “I’m told it was Olive’s favorite dessert,” said Jest. “Now I’m not saying I believe in ghosts. I’m just saying every time I bake a peach pie, the dang thing disappears from the cooling rack. Same with chocolate-chip muffins.” Les and Diane Hope were well aware of the history of SpenceMan

sion when they purchased the house 12 years ago after it had sat empty for more than eight decades. As professors of the paranormal, the Hopes had hoped to study and document the ghost of Olive C. Spence.“If we can get Olive’s ghost to perform, we’ll make a fortune,” Les Hope said the day he and his

wife moved into the house.“We’ll be the richest professors of the paranormal in America,” Diane Hope added. “Maybe the whole world!”But when repeated experiments failed to detect any evidence of ghosts in Spence Mansion, Les and Diane Hope put the house up for sale. They are spending the summer on

a tour of Europe, promoting their research conclusions in a lecture entitled “Only Fools (and Children) Believein Ghosts.”The Hopes left their only child, Seymour, behind for professional reasons.

基隆市 圖書館 借 書證進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決基隆市 圖書館 借 書證的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.