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Amazing Animals Activities & Stickers

為了解決Importance的問題，作者Bright, J. E. (ILT)/ Clever Publishing (COR) 這樣論述：

The colorful pages of AMAZING ANIMALS ACTIVITIES & STICKERS are packed with fluffy mammals, scaly reptiles, swimming sea creatures, and flying birds The entertaining activities include matching games, mazes, word searches, number challenges, decoder games, and fun facts - all designed to keep busy

young minds engaged.With lots and lots of fun-filled stickers, kids will develop hand-eye coordination and early skills as they play.The handy take-along format is perfect for kids on the go J.E. Bright is the writer of more than 120 novels, novelizations, non-fiction books, interactive storybook

apps, and novelty books for children and young adults. He was a children’s book editor for almost 20 years, at publishing companies including Scholastic, HarperCollins, and Simon & Schuster. Now he writes full time.Clever Publishing was founded in 2010 with the purpose of changing children’s lives

for the better. We create a world full of fascinating experiences for families through our books, games, sets, and series. Focusing on Pre-school and Edutainment, we’ve developed a wide range of innovative formats with modern teaching techniques. Kids love to read, touch, and play while learning, so

our program includes products for all ages, including box sets; board books; puzzle books; learning flash cards; interactive coloring, activity, and word play formats; and boards games for the entire family. Our dream team - more than 100 employees worldwide - have a comprehensive understanding and

knowledge of children’s books. With this expertise, we present products that are fun, entertaining, and vibrant. We are modern and educational and strive to always emphasize the importance of first experiences. We connect to the needs of busy parents and aim to enrich the time spent with their chil

dren. Our goal is to make children - as well as their parents happy!

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Importance的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Dowding & Churchill: The Dark Side of the Battle of Britain

為了解決Importance的問題，作者Dixon, Jack 這樣論述：

Air Chief Marshal Sir Hugh - later Lord - Dowding was one of the greatest Englishmen of the 20th century. He created Fighter Command with its unique early warning system (radar) from nothing in 1936 to the efficient defensive force it became in 1940. In consequence Fighter Command was the only ar

m that was properly prepared for battle when war was declared against Germany. Hugh Dowding led Fighter Command in the Battle of Britain, and was victorious. The campaign, although a series of defensive engagements, was one of the decisive battles of Western Civilization. The strategic importance of

the Battle of Britain was recognized at the time, yet, the moment it was won Dowding was summarily relieved of his command and shuffled into retirement without recognition, reward or promotion. This book reveals that this was the result of a shabby conspiracy by fellow officers. The Air Ministry pu

blished a brief account of the Battle in March 1941 and in it there was no mention of Dowding. Churchill was furiously indignant. But in November 1940 he had acquiesced in Dowding's removal. Why? And what are the factors that led to Dowding's dismissal in the first place? In this thought-provoking a

nd authoritative book Jack Dixon answers these questions and explains Dowding's true greatness

以線上三級介入模式提升國中普通班教師正向行為支持知識之研究

為了解決Importance的問題，作者潘淳威 這樣論述：

本研究目的為探討以線上三級介入模式提升國中普通班教師正向行為支持知識之成效以及看法。研究方法採單一受試實驗之變更情境設計，以6名國中普通班教師為研究參與者，採用三級介入模式進行線上培訓，依序以自學、團體工作坊、一對一教練方式進行，每一階段評量結果未達90%之參與者進入下一階段接受介入，介入完成後填寫回饋調查。將所蒐集之量化資料進行視覺分析，並統整參與者回饋等相關質性資料，得到以下發現。一、 以線上三級介入模式實施正向行為支持課程，有2位教師能在次級達通過標準。二、 以線上三級介入模式實施正向行為支持課程，可提升6位教師正向行為支持的知識，其中2位教師達通過標準。三、 5位教師認同以行為技能訓

練融入教材與教學有助於學習與操作，4位教師對本教材持肯定態度。四、 4位教師認同線上三級模式可提供他們在學習上不同程度的支持、能滿足其學習風格與偏好。五、 4位教師認為正向行為支持對處理學生行為問題有幫助，願意在未來使用，並有信心能預防行為問題。