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American Manhood: A Concise History of Masculinity in U.s. History and Culture

為了解決Reveal的問題，作者Carroll, Bret 這樣論述：

While the concepts of manhood and masculinity have assumed an established place in gender and historical studies and masculinity is the subject of wide popular interest and discussion, there is currently no up-to-date, comprehensive historical overview of the subject. American Manhood will introd

uce readers to the dynamic interplay between the perceptions and experiences we call "masculinity" and major social, cultural, political, and economic developments in our history. Its central argument will be that Americans of different racial, class, ethnic, and regional groups have historically us

ed concepts of masculine identity to gender relations of power and national belonging in ways that attempt either to entrench or to stake their claims to positions of authority and legitimacy in American life. Gender, the book assumes and will demonstrate, provides a crucial analytic category for un

derstanding U.S. history. The book will cover the period from roughly the early seventeenth century to the present. It will utilize a combination of chronological and topical approaches to present a state-of-the-art narrative, reflective of current historical scholarship, to a broad general audience

. The anticipated audience will bring to their reading a familiarity with recent popular discussions of masculinity; American Manhood will use accessible prose to reveal to them the enormous complexity, diversity, and historical rootedness of the topic - to deepen readers' understanding of a subject

they thought they knew.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Reveal的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Murder Ballads Old and New: A Dark and Bloody Record

為了解決Reveal的問題，作者 這樣論述：

Murder Ballads Old & New: A Dark and Bloody Record is an exploration of an age-old topic-- our human need to document the horrors of the world around us. The murder ballad, here expanded to include songs about traumatic loss in modern variants and multiple styles, including punk, post-punk, alt-coun

try, and folk. The book is a graveyard stroll past tombs both well-kept and half-hidden. Murder Ballads Old & New excavates facts about killers, victims, and the folkloric storytellers who disseminated their tales in song.Author Steven L. Jones focuses the tragic ballad as ＂an act of remembering and

a soul-reckoning with the ineffable.＂ Songs examined range from obscure tunes from the founding days of the United States to familiar canonical songs learned in schoolrooms and honkytonks. Jones tackles each song in a manner that’s equal parts musicological, psychosocial, and genealogical as he unc

overs stories that reveal larger contexts and maps the lineages of songs and themes, forebears, and ancestors. Murder Ballads Old & New includes a wide range of songs and performers from the relatively unknown (Boiled in Lead, Freakons, Nelstone’s Hawaiians) to the ironically famous (Johnny Cash, Lo

u Reed, Sonic Youth). Highlightsinclude tales of Muddy Waters guitar sideman Pat Hare, whose incendiary blues boast ＂I’m Gonna Murder My Baby＂ proved grimly prophetic. And honky-tonk pioneer Eddie Noack, whose morbid stab at late-career rebirth, ＂Psycho,＂ couldn’t match the bottomless tragedy of his

own life. As well as Depression-era holdup man Pretty Boy Floyd, Schubert’s mythical Erlkönig, and the Manson Family.Murder Ballads Old & New is a compelling delve into the perennial American fascination with True Crime. Includes archival and historical black & white images.

具新穎氮硫化鎢界面結構的p型二硫化鎢電晶體: 以第一原理量子傳輸理論進行模擬計算

為了解決Reveal的問題，作者歐仲鎧 這樣論述：

實驗室所製作的過渡金屬二硫族化合物(含一定濃度缺陷)二維電晶體，由於費米能釘札導致其p型接觸非常稀少；另一方面，電腦計算模擬所對應的上述理想結構(二維材料無缺陷)則可在高功函數金屬顯出為p型接觸，但仍未達到足夠低的電洞蕭特基位障。因此本文提出一種金屬性的超材料硫氮化鎢作為傳統金屬與半導體通道之間的緩衝層。其結構的形成可揣摩是由簡單的metal/WS2側接觸做為出發，我將鄰近介面處一定面積的上排硫原子置換為氮。以第一原理及量子傳輸理論計算電子結構與傳輸電流。我發現在金屬與二硫化鎢之間僅需0.6奈米長的硫氮化鎢緩衝層，便可有效降低通道的電洞蕭特基位障：在以鉑為金屬電極的情形中，硫氮化鎢可使蕭特基

型的Pt/WS2側接觸轉變為歐姆特性，達成以單一二維材料實現互補式金屬氧化物半導體的目標。除了鉑電極，即便我採用低功函數的金屬鋁，在Al/WSN/WS2的結構，計算而得的蕭特基位障仍低至0.12 eV。上述鉑與鋁電極的計算結果表明，氮硫化鎢緩衝層顯著提升了選擇電極金屬的靈活性，令選擇不再受限於高功函數的貴重金屬：如金、鉑和鈀。我亦更進一步量化計算Pt/WSN/WS2在不同閘極電壓下的伏安特性，得出該結構有高達10^8的開關電流比和在汲極電壓50毫伏下231 µA/µm的導通電流(接觸電阻 ≈ 63.8Ω∙μm)。同時為驗證實驗製程時硫氮化鎢的穩定性，我們採用第一原理分子動力學在室溫下分別模擬氮

吸附、單顆氮取代硫和單層氮硫化鎢，發覺皆為穩定結構。