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Jazz (15th Anniversary Edition)

為了解決br的問題，作者Myers, Walter Dean 這樣論述：

Featuring a new introduction from best-selling author Jacqueline Woodson, anew edition of the award-winning father-son collaboration that celebrates the great American art form.One of TIME’s 100 Best Children’s Books of All Time Walter Dean Myers was one of the best-loved and most influential wri

ters of his generation. Originally published 15 years ago, this Coretta Scott King Honoree Jazz now features a new introduction about the ground-breaking author written by his son, Christopher. In this book that sings with the rhythm and wordplay of jazz, fifteen poems, are paired with bold, stylize

d illustrations of performers and dancers to convey the history and breadth of this unique musical style. From bebop to New Orleans, from ragtime to boogie, and every style in between, Jazz takes readers on a musical journey from jazz’s beginnings to the present day. The book includes a brief introd

uctory essay about the history and form of jazz, as well as a timeline and glossary of jazz terms. Coretta Scott King Award Honor for illustrationALA Notable Children’s BookLee Bennett Hopkins Poetry AwardPublishers Weekly’s 100 Best Books of the YearKirkus Reviews Editor’s ChoiceBooklist Editor’s C

hoiceBooklist Top Ten in Black HistoryBook Link’s Best New Books for the ClassroomGolden Kite Award: Picture Book Text

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決br的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Night Before Christmas Pop Up Book: A Pop-Up Edition

為了解決br的問題，作者Moore, Clement 這樣論述：

This magnificent Christmas Eve poem is brought to life in this pop-up edition of the #1 New York Times best seller The Night Before Christmas. ’Twas the night before Christmas, when all through the house, Not a creature was stirring, not even a mouse... This holiday season enjoy everyone’s favor

ite Christmas Eve poem with this beautiful pop-up book. Every child knows the words to this captivating story, and this delightful edition provides an exciting 3D reading experience for children and parents alike. Join Dasher, Dancer, Prancer, Vixen, Comet, Cupid, Donder, and Blitzen and dash your w

ay through these dynamic pages. Not only will this Christmas poem spread holiday cheer, it will engage your child and encourage a love of reading. This edition includes: - 3D pop-up elements that offer a new take on this nostalgic Christmas classic - A beautifully designed hardcover with an embosse

d foil-stamped cover - Clement C. Moore’s original text, including a nod to Dutch references in the poem, specifically the Dutch name ＂Donder,＂ which translates to ＂thunder＂ - Stunning artwork by #1 New York Times best-selling illustrator Charles Santore. Start a new family tradition this year or

carry on your own with this illuminating edition of a timeless tale. You’ll be sharing this holiday classic with children and family for years to come. The work of New York Times bestselling children’s book illustrator Charles Santore has been widely exhibited in museums and celebrated with recognit

ions such as the prestigious Hamilton King Award, the Society of Illustrators Award of Excellence, and the Original Art 2000 Gold Medal from the Society of Illustrators. He is best known for his luminous interpretations of classic children’s stories, including The Little Mermaid, Alice’s Adventures

in Wonderland, Snow White, and The Wizard of Oz.

用於染料敏化電池的無金屬有機染料之結構設計

為了解決br的問題，作者吳杰畢 這樣論述：

摘要第三代光伏的染料敏化太陽能電池 (DSSC)的興起，造成在過去的三十年中被廣泛地探索，因為它們具有的獨特特性，例如成本低、製造工藝簡單、輕巧、柔韌性好、對環境友善，並且在弱光條件下，仍具備突破性的高效率。儘管， DSSCs 依然有許多須待優化的部分，但藉由光捕獲染料光敏劑的分子結構設計，在優化 DSSCs 性能參數方面扮演關鍵的作用。因此，尋找符合DSSC需求的光敏染料，是該研究領域的關鍵研究方向之一。本論文的最終目標是在標準日照和弱光條件下，尋找高效穩定的有機光敏染料。這項工作是藉由無金屬有機光敏劑的系統結構工程來完成的，針對分子結構設計與光電特性的關聯及DSSC的效能表現。在本論文中

，我們已經合成了各種新型光敏染料，並對這些無金屬有機光敏染料進行了逐步的結構修飾，例如在單個敏化染料中引入一對輔助受體，在 D-A-π-A 框架中引入龐大的芴基實體，並增加共平面性以及延伸喹喔啉染料主要框架的共軛。通過使用各種光譜、電化學和理論計算來研究這些光敏染料的結構性質，以符合它們在DSSC主要特徵之應用前景。最後，在本論文中，我們展示了一組無金屬有機光敏劑，其元件效率高，在標準太陽照射下的效率超過 9%，在 6000 lux 的弱光照下，效率超過 30%，這將是一個具有未來發展潛力的結構設計，可以在沒有共吸附劑的情況下實現高效率。